N-(4-Chloro-phen-yl)-1,1,1-trifluoro-N-(trifluoro-methyl-sulfon-yl)methane-sulfonamide.

The title mol-ecule, also called 4-chloro-N,N-bis-(trifluoro-methane-sulfon-yl)aniline, C(8)H(4)ClF(6)NO(4)S(2), has non-crystallographic twofold symmetry with the pseudo-axis aligned along the Cl-C⋯C-N backbone of the mol-ecule: the SO(2)CF(3) residues lie to either side of the benzene ring. In the crystal, the presence of C-H⋯O contacts lead to the formation of a sequence of 12-membered {⋯HC(2)NSO}(2) synthons within a supra-molecular chain aligned along [101].

2-Chloro-6,6-dimethyl-5,6-dihydro-indazolo[2,3-c]quinazoline.

Two independent but virtually identical mol-ecules comprise the asymmetric unit of the title compound, C(16)H(14)ClN(3). The mol-ecules have a slightly curved shape owing to puckering in the six-membered C(4)N(2) ring; the respective dihedral angles formed between the benzene rings are 12.64 (7) and 11.72 (7)°. In the crystal, layers sustained by a combination of N-H⋯N hydrogen bonding as well as C-H⋯N and C-H⋯π contacts are formed; these stack along [011] and are connected by further C-H⋯π contacts.

N-(4-Chloro-phen-yl)ethanimidamide.

A twisted conformation is found in the title compound, C(8)H(9)ClN(2), with the ethanimidamide residue being twisted substantially to the benzene ring [dihedral angle = 66.54 (14)°]. The conformation about the C=N double bond [1.299 (3) Å] is Z. A two-dimensional array with a zigzag topology is formed in the crystal structure via N-H⋯N and N-H⋯Cl hydrogen-bonding inter-actions.

Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents.

Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.